This lesson is general education from the handbooks and the rules. It is not medical advice.
PREDICT FIRST
You climb from sea level to 18,000 ft. What happens to the share of the air that is oxygen?
Thinner air
Hypoxia is a shortage of oxygen. PHAK's chief worry in flight is the brain.
Hypoxia means “reduced oxygen” or “not enough oxygen.” Although any tissue will die if deprived of oxygen long enough, the greatest concern regarding hypoxia during flight is lack of oxygen to the brain, since it is particularly vulnerable to oxygen deprivation.
At height the air holds the same share of oxygen, but at a lower pressure, so fewer oxygen molecules are available at the pressure they need to pass between the membranes in the respiratory system. The simulation shows oxygen's partial pressure as dots, beside a box of sea level air.
PREDICT FIRST
A pilot climbs to 16,000 ft without supplemental oxygen and is asked how they feel. Which answer does PHAK warn you to expect?